Effects of smoked marijuana in experimentally induced asthma

[Sequoiacrone]

TitleEffects of smoked marijuana in experimentally induced asthma.
Author(s)Tashkin DP, Shapiro BJ, Lee YE, Harper CE

Journal, Volume, IssueAmerican Review of Respiratory Disease 1975;112(3):377-386Major outcome(s)after experimental induction of acute bronchospasm prompt correction of the bronchospasm with cannabis

IndicationAsthmaAbstractMedicationCannabis:

After experimental induction of acute bronchospasm in 8 subjects with clinically stable bronchial asthma, effects of 500 mg of smoked marijuana (2.0 per cent delta9-tetrahydrocannabinol) on specific airway conductance and thoracic gas volume were compared with those of 500 mg of smoked placebo marijuana (0.0 per cent delta9- tetrahydrocannabinol), 0.25 ml of aerosolized saline, and 0.25 ml of aerosolized isoproterenol (1,250 mug). Bronchospasm was induced on 4 separate occasions, by inhalation of methacholine and, on four other occasions, by exercise on a bicycle ergometer or treadmill.

Methacholine and exercise caused average decreases in specific airway conductance of 40 to 55 per cent and 30 to 39 per cent, respectively, and average increases in thoracic gas volume of 35 to 43 per cent and 25 to 35 per cent, respectively.

After methacholine-induced bronchospasm, placebo marijuana and saline inhalation produced minimal changes in specific airway conductance and thoracic gas volume, whereas 2.0 per cent marijuana and isoproterenol each caused a prompt correction of the bronchospasm and associated hyperinflation.
After exercise-induced bronchospasm, placebo marijuana and saline were followed by gradual recovery during 30 to 60 min, whereas 2.0 per cent marijuana and isoproterenol caused an immediate reversal of exercise-induced asthma and hyperinflation.

Route(s)InhalationDose(s)smoked cannabis (2.0% THC)Duration (days)1Participants8 asthmatic subjectsDesignControlled studyType of publicationAddress of author(s)Full text

for more research see here....see link for the IACM too.
http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=57
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[Sequoiacrone]

TitleAcute effects of smoked marijuana and oral delta9-tetrahydrocannabinol on specific airway conductance in asthmatic subjects.

Author(s)Tashkin DP, Shapiro BJ, Frank IM.

Journal, Volume, IssueAmerican Review for Respiratory Diseases. 1974 Apr;109(4):420-8.
Major outcome(s)Smoked marijuana and oral THC caused significant bronchodilation of at least 2 hours duration.
IndicationAsthmaAbstractMedicationCannabis;Delta-9-THC;CannabidiolThe acute effects of smoked 2 per cent natural marijuana (7 mg per kg) and 15 mg of oral Delta-9-tetrahydrocannabinol (THC) on plethysmographically determined airway resistance (Raw) and specific airway conductance (SGaw) were compared with those of placebo in 10 subjects with stable bronchial asthma using a double-blind crossover technique.

After smoked marijuana, SGaw increased immediately and remained significantly elevated (33 to 48 per cent above initial control values) for at least 2 hours, whereas SGaw did not change after placebo. The peak bronchodilator effect of 1,250 myg of isoproterenol was more pronounced than that of marijuana, but the effect of marijuana lasted longer.

After ingestion of 15 mg of THC, SGaw was elevated significantly at 1 and 2 hours, and Raw was reduced significantly at 1 to 4 hours, whereas no changes were noted after placebo. These findings indicated that in the asthmatic subjects, both smoked marijuana and oral THC caused significant bronchodilation of at least 2 hours duration.

Route(s)Inhalation;OralDose(s)Duration (days)Participants10 subjects with stable bronchial asthmaDesignControlled studyType of publicationMedical journalAddress of author(s)Full text

see here for more information
http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=67