VAPORIZATION AS A SMOKELESS CANNABIS DELIVERY SYSTEM:

[Sequoiacrone]

VAPORIZATION AS A SMOKELESS CANNABIS DELIVERY SYSTEM:
A PILOT STUDY
Donald I. Abrams, Hector P. Vizoso, Starley B. Shade, Cheryl Jay, Mary Ellen Kelly and Neal Benowitz
The University of California San Francisco, San Francisco, California 94110, USA
INTRODUCTION: The Institute of Medicine report published in 1999 suggested that although
marijuana may have potential therapeutic value, smoking was not a desirable delivery system for
cannabis. A 6-day “proof of concept” pilot study was proposed to investigate vaporization using the
Volcano device as an alternative means of delivery of inhaled Cannabis sativa, to characterize
preliminary pharmacokinetic and pharmacodynamic effects and to determine whether it may be an
appropriate system for use in clinical effectiveness studies.


CONCLUSION: Vaporization of cannabis is a safe mode of delivery. The determination of plasma
THC levels and comparison of clinical effects to smoked cannabis will provide information on the
effectiveness of this delivery system. Participants had a clear preference for vaporization over smoking
as a delivery system for the cannabis used in this trial.
Acknowledgements: The University of California Center for Medicinal Cannabis Research and NIH
Grant 5-MO1-RR00083


For the entire article see here:
http://www.cmcr.ucsd.edu/geninfo/abrams_vap_abs_1.pdf

[Sequoiacrone]

esearch (http://www.nature.com/clpt/journal/v82/n5/index.html#Research) > Abstract Article

Clinical Pharmacology & Therapeutics (2007) 82, 572–578; doi:10.1038/sj.clpt.6100200; published online 11 April 2007
Vaporization as a Smokeless Cannabis Delivery System: A Pilot Study

D I Abrams1 (http://www.nature.com/clpt/journal/v82/n5/abs/6100200a.html#aff1),2 (http://www.nature.com/clpt/journal/v82/n5/abs/6100200a.html#aff2),3 (http://www.nature.com/clpt/journal/v82/n5/abs/6100200a.html#aff3), H P Vizoso1 (http://www.nature.com/clpt/journal/v82/n5/abs/6100200a.html#aff1),3 (http://www.nature.com/clpt/journal/v82/n5/abs/6100200a.html#aff3), S B Shade1 (http://www.nature.com/clpt/journal/v82/n5/abs/6100200a.html#aff1),3 (http://www.nature.com/clpt/journal/v82/n5/abs/6100200a.html#aff3), C Jay4 (http://www.nature.com/clpt/journal/v82/n5/abs/6100200a.html#aff4),5 (http://www.nature.com/clpt/journal/v82/n5/abs/6100200a.html#aff5), M E Kelly1 (http://www.nature.com/clpt/journal/v82/n5/abs/6100200a.html#aff1),2 (http://www.nature.com/clpt/journal/v82/n5/abs/6100200a.html#aff2),3 (http://www.nature.com/clpt/journal/v82/n5/abs/6100200a.html#aff3) and N L Benowitz3 (http://www.nature.com/clpt/journal/v82/n5/abs/6100200a.html#aff3),6 (http://www.nature.com/clpt/journal/v82/n5/abs/6100200a.html#aff6)


1Community Consortium, Positive Health Program, San Francisco General Hospital, San Francisco, California, USA
2Division of Hematology-Oncology, San Francisco General Hospital, San Francisco, California, USA
3Department of Medicine, University of California, San Francisco, California, USA
4Division of Neurology, San Francisco General Hospital, San Francisco, California, USA
5Department of Neurology, University of California, San Francisco, California, USA
6Division of Clinical Pharmacology and Experimental Therapeutics, University of California, San Francisco, California, USA

Correspondence: DI Abrams, (dabrams@php.ucsf.edu)
Received 29 September 2006; Accepted 25 February 2007; Published online 11 April 2007.

Top of page (http://www.nature.com/clpt/journal/v82/n5/abs/6100200a.html#top)Abstract

Although cannabis may have potential therapeutic value, inhalation of a combustion product is an undesirable delivery system. The aim of the study was to investigate vaporization using the Volcano® device as an alternative means of delivery of inhaled Cannabis sativa. Eighteen healthy inpatient subjects enrolled to compare the delivery of cannabinoids by vaporization to marijuana smoked in a standard cigarette. One strength (1.7, 3.4, or 6.8% tetrahydrocannabinol (THC)) and delivery system was randomly assigned for each of the 6 study days. Plasma concentrations of http://www.nature.com/__chars/_delta/black/med/base/glyph.gif-9-THC, expired carbon monoxide (CO), physiologic and neuropsychologic effects were the main outcome measures. Peak plasma concentrations and 6-h area under the plasma concentration–time curve of THC were similar. CO levels were reduced with vaporization. No adverse events occurred. Vaporization of cannabis is a safe and effective mode of delivery of THC. Further trials of clinical effectiveness of cannabis could utilize vaporization as a smokeless delivery system.


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Vaporization as a Smokeless Cannabis Delivery System: A Pilot Study (http://www.nature.com/doifinder/10.1038/sj.clpt.6100200)Clinical Pharmacology & Therapeutics Article Response
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